In terms of overall gaming performance, the graphical capabilities of the Nvidia Quadro M4000 are noticeably better than the AMD FirePro S9150.

The FirePro S9150 has a 127 MHz higher core clock speed and 72 more Texture Mapping Units than the Quadro M4000. This results in the FirePro S9150 providing 78 GTexel/s better texturing performance. This still holds weight but shader performance is generally more relevant, particularly since both of these GPUs support at least DirectX 10.

The FirePro S9150 has a 127 MHz higher core clock speed and 8 more Render Output Units than the Quadro M4000. This results in the FirePro S9150 providing 14.3 GPixel/s better pixeling performance. However, both GPUs support DirectX 9 or above, and pixeling performance is only really relevant when comparing older cards.

The Quadro M4000 was released less than a year after the FirePro S9150, and so they are likely to have similar driver support for optimizing performance when running the latest games.

Both GPUs exhibit very powerful performance, so it probably isn't worth upgrading from one to the other, as both are capable of running even the most demanding games at the highest settings.

The FirePro S9150 has 8192 MB more video memory than the Quadro M4000, so is likely to be much better at displaying game textures at higher resolutions. This is supported by the fact that the FirePro S9150 also has superior memory performance overall.

The FirePro S9150 has 127.7 GB/sec greater memory bandwidth than the Quadro M4000, which means that the memory performance of the FirePro S9150 is massively better than the Quadro M4000.

The Quadro M4000 has 1664 Shader Processing Units and the FirePro S9150 has 2816. However, the actual shader performance of the Quadro M4000 is 1736 and the actual shader performance of the FirePro S9150 is 2534. The FirePro S9150 having 798 better shader performance and an altogether better performance when taking into account other relevant data means that the FirePro S9150 delivers a massively smoother and more efficient experience when processing graphical data than the Quadro M4000.

The Quadro M4000 requires 120 Watts to run and the FirePro S9150 requires 235 Watts. We would recommend a PSU with at least 450 Watts for the Quadro M4000. The FirePro S9150 requires 115 Watts more than the Quadro M4000 to run. The difference is significant enough that the FirePro S9150 may have an adverse affect on your yearly electricity bills in comparison to the Quadro M4000.