In terms of overall gaming performance, the graphical capabilities of the AMD Radeon R9 M365X 4GB are massively better than the Nvidia Quadro 1000M.

The R9 M365X was released over three years more recently than the Quadro 1000M, and so the R9 M365X is likely to have far better driver support, meaning it will be much more optimized and ultimately superior to the Quadro 1000M when running the latest games.

The R9 M365X has 2048 MB more video memory than the Quadro 1000M, so is likely to be much better at displaying game textures at higher resolutions. This is supported by the fact that the R9 M365X also has superior memory performance overall.

The R9 M365X has 35.2 GB/sec greater memory bandwidth than the Quadro 1000M, which means that the memory performance of the R9 M365X is noticeably better than the Quadro 1000M.

The Radeon R9 M365X 4GB has 640 Shader Processing Units and the Quadro 1000M has 96. However, the actual shader performance of the R9 M365X is 340 and the actual shader performance of the Quadro 1000M is 67. The R9 M365X having 273 better shader performance and an altogether better performance when taking into account other relevant data means that the R9 M365X delivers a significantly smoother and more efficient experience when processing graphical data than the Quadro 1000M.

The R9 M365X transistor size technology is 12 nm (nanometers) smaller than the Quadro 1000M. This means that the R9 M365X is expected to run slightly cooler and achieve higher clock frequencies than the Quadro 1000M.

The Radeon R9 M365X 4GB requires 50 Watts to run and the Quadro 1000M requires 45 Watts. The R9 M365X requires 5 Watts more than the Quadro 1000M to run. The difference is not significant enough for the R9 M365X to have a noticeably larger impact on your yearly electricity bills than the Quadro 1000M.