In terms of overall gaming performance, the graphical capabilities of the AMD Radeon HD 7970M Crossfire are massively better than the AMD Radeon R9 M365X 4GB.

The HD 7970M has a 225 MHz higher core clock speed and 120 more Texture Mapping Units than the R9 M365X. This results in the HD 7970M providing 111 GTexel/s better texturing performance. This still holds weight but shader performance is generally more relevant, particularly since both of these GPUs support at least DirectX 10.

The HD 7970M has a 225 MHz higher core clock speed and 48 more Render Output Units than the R9 M365X. This results in the HD 7970M providing 44.4 GPixel/s better pixeling performance. However, both GPUs support DirectX 9 or above, and pixeling performance is only really relevant when comparing older cards.

The R9 M365X was released over three years more recently than the HD 7970M, and so the R9 M365X is likely to have far better driver support, meaning it will be much more optimized and ultimately superior to the HD 7970M when running the latest games.

The Radeon R9 M365X 4GB and the Radeon HD 7970M Crossfire have the same amount of video memory, but are likely to provide slightly different experiences when displaying game textures at high resolutions.

The HD 7970M has 243.2 GB/sec greater memory bandwidth than the R9 M365X, which means that the memory performance of the HD 7970M is massively better than the R9 M365X.

The Radeon R9 M365X 4GB has 640 Shader Processing Units and the Radeon HD 7970M Crossfire has 2560. However, the actual shader performance of the R9 M365X is 340 and the actual shader performance of the HD 7970M is 1850. The HD 7970M having 1510 better shader performance and an altogether better performance when taking into account other relevant data means that the HD 7970M delivers a massively smoother and more efficient experience when processing graphical data than the R9 M365X.

The Radeon R9 M365X 4GB requires 50 Watts to run and the Radeon HD 7970M Crossfire requires 200 Watts. The HD 7970M requires 150 Watts more than the R9 M365X to run. The difference is significant enough that the HD 7970M may have an adverse affect on your yearly electricity bills in comparison to the R9 M365X.