In terms of overall gaming performance, the graphical capabilities of the Nvidia GeForce GTX 460M SLI are significantly better than the AMD Radeon R9 M365X 4GB.

The GTX 460M has a 50 MHz higher core clock speed and 24 more Texture Mapping Units than the R9 M365X. This results in the GTX 460M providing 18.2 GTexel/s better texturing performance. This still holds weight but shader performance is generally more relevant, particularly since both of these GPUs support at least DirectX 10.

The GTX 460M has a 50 MHz higher core clock speed and 32 more Render Output Units than the R9 M365X. This results in the GTX 460M providing 22.4 GPixel/s better pixeling performance. However, both GPUs support DirectX 9 or above, and pixeling performance is only really relevant when comparing older cards.

The R9 M365X was released over three years more recently than the GTX 460M, and so the R9 M365X is likely to have far better driver support, meaning it will be much more optimized and ultimately superior to the GTX 460M when running the latest games.

The R9 M365X has 1024 MB more video memory than the GTX 460M, so is likely to be much better at displaying game textures at higher resolutions. However, the overall memory performance is about the same.

The GTX 460M has 56 GB/sec greater memory bandwidth than the R9 M365X, which means that the memory performance of the GTX 460M is much better than the R9 M365X.

The Radeon R9 M365X 4GB has 640 Shader Processing Units and the GeForce GTX 460M SLI has 384. However, the actual shader performance of the R9 M365X is 340 and the actual shader performance of the GTX 460M is 518. The GTX 460M having 178 better shader performance and an altogether better performance when taking into account other relevant data means that the GTX 460M delivers a significantly smoother and more efficient experience when processing graphical data than the R9 M365X.

The R9 M365X transistor size technology is 12 nm (nanometers) smaller than the GTX 460M. This means that the R9 M365X is expected to run slightly cooler and achieve higher clock frequencies than the GTX 460M.

The Radeon R9 M365X 4GB requires 50 Watts to run and the GeForce GTX 460M SLI requires 100 Watts. The GTX 460M requires 50 Watts more than the R9 M365X to run. The difference is significant enough that the GTX 460M may have a slight adverse affect on your yearly electricity bills in comparison to the R9 M365X.